峰值呼气流的纵向变化预测了发生痴呆症的风险
Patrick T Donahue1,2, Aparna Balasubramanian3, Qian-Li Xue2,4
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
概括
呼吸功能下降,以峰值呼气流量 (PEF) 衡量,显著增加老年人痴呆症的风险. 这项研究强调PEF是认知衰退和痴呆症预防策略的关键指标.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 肺部病理学 肺部病理学
背景情况:
- 呼吸功能受损,以峰值呼气流 (PEF) 表示,与更高的痴呆风险有关.
- 现有的研究主要使用横截面PEF数据,使纵向关联未得到充分研究.
研究的目的:
- 研究呼吸功能变化 (PEF) 与老年人患痴呆症的风险之间的纵向关联.
- 为了确定PEF在五年内下降的速度是否预测随后的五年内发生的痴呆症.
主要方法:
- 利用了国家健康和衰老趋势研究中65岁以上的2,439名成年人10年的数据 (2011-2021年).
- 使用线性混合效应模型估计了5年PEF变化 (2011-2016),并将其分类为四分位数.
- 采用离散时间的Cox比例危险模型来评估痴呆风险,控制共变量.
主要成果:
- 与没有PEF下降相比,PEF快速下降 (2011-2016) 与发生痴呆症的风险增加85% (2017-2021) 相关.
- 在5年的随访期间,发现了338例 (13.9%) 发生性痴呆症.
- 在所有灵敏度分析中,调查结果保持稳健.
结论:
- 峰值呼气流量的下降可能会先于认知衰退,将呼吸功能定位为老年人群中痴呆症的重要危险因素.
- 峰值流量计提供了一种简单,具有成本效益的方法来评估呼吸功能,并可能识别患痴呆症风险较高的人.
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