低肺功能与心血管死亡率的高人口归因部分有关
Surya P Bhatt1, Chaoqi Wu2, Yifei Sun2
1Division of Pulmonary, Allergy, and Critical Care Medicine, Center for Lung Analytics and Imaging Research, University of Alabama at Birmingham, Birmingham, Alabama.
Annals of the American Thoracic Society
|October 24, 2024
概括
低肺功能显著导致冠心病 (CHD) 死亡率,排名为主要风险因素. 这一发现凸显了肺功能评估在心血管风险评估中的重要性.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 慢性肺部疾病与冠心病 (CHD) 死亡率的增加有关.
- 对心血管疾病死亡率的肺功能障碍的人口归因分数 (PAF) 尚未得到充分确立.
- 了解肺功能在心血管风险中的作用对于公共卫生至关重要.
研究的目的:
- 确定对冠心病 (CHD) 死亡率低肺功能的人口归因分数 (PAF).
- 为了比较低肺功能的影响与其他已确定的心血管风险因素.
主要方法:
- 汇集了来自美国八个普通人口队伍的数据,包括螺旋测量和临床数据.
- 肺功能受损定义为1秒内强制呼气体积 (FEV1) 和/或预测的强制生命能力≤95%.
- 使用因果特定的比例危险和细灰色模型,调整多个心血管风险因素和竞争风险.
主要成果:
- 低FEV1 (预测≤95%) 与心血管疾病死亡率的1.30危险比率有关.
- 低FEV1的PAF为12%,使其成为CHD死亡率的第三大可归因风险因素,仅次于高血压和糖尿病.
- 在活跃吸烟者中,低FEV1占心血管疾病死亡率的14%,排在高血压之后的第二位.
结论:
- 降低肺功能,即使在临床正常范围内,也是心血管疾病死亡率的重要可归因风险因素.
- 肺功能评估应纳入心血管风险分层策略.
- 这项研究强调了呼吸道和心血管健康的相互联系.
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