在人类微生物组中扩大β-乳酸酶家族
Baolei Jia1,2, Ju Hye Baek2, Jae Kyeong Lee2
1Xianghu Laboratory, Hangzhou, 311231, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|October 24, 2024
概括
抗生素耐药性是一个越来越令人担忧的问题. 这项研究揭示了对人类肠道微生物群中的β-乳糖酶多样性和丰富性的新见解,将其与抗生素使用和各种疾病联系起来.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 药理学 药理学是指药理学的学科.
背景情况:
- β-乳糖胺是广泛使用的抗生素,耐药性通常由β-乳糖胺酶介导.
- 人类微生物群中的β-乳糖酶的多样性和丰富性尚未完全理解.
- 了解这些酶对于打击抗生素耐药性至关重要.
研究的目的:
- 来自微生物来源的新型β-乳酸酶的识别和特征.
- 在全球范围内量化人类肠道微生物群中的β-乳糖酶的丰富性和多样性.
- 调查β-乳糖酶丰富度,抗生素消费,社会经济因素和人类疾病之间的相关性.
主要方法:
- 对蛋白质数据库的生物信息分析,以确定假定的β-乳酸酶序列.
- 聚类分析和生物化学测定以确认新型β-乳糖酶.
- 来自19个国家的健康个体的肠道微生物群样本的定量分析.
- 统计分析以将β-乳糖酶丰度与临床和人口统计数据相关联.
主要成果:
- 确定了九种新的β-乳酸酶,属于八个不同的群.
- 在全球范围内观察到肠道β-乳糖酶丰度的显著变化,日本显示最高,斐济显示最低.
- β-乳糖酶的丰度与β-乳糖的消费和国民收入正相关.
- 肠道β-乳糖酶丰度增加与结直肠癌,心血管疾病,乳腺癌和有关.
结论:
- 这项研究扩大了已知的β-乳酸酶的范围,并提供了它们在人体肠道中的存在的全球快照.
- 肠道β-乳糖酶的丰富程度受抗生素使用和社会经济因素的影响.
- 肠道中的β-乳糖酶水平升高与几种重要的人类疾病有关,这突显了它们的临床相关性.
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