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珀塔克缺乏症的流行 Bordetella pertussis 隔离物,斯洛文尼亚

Alex-Mikael Barkoff, Tamara Kastrin, Katja Seme

Emerging infectious diseases

|October 24, 2024

概括

斯洛文尼亚的变化

科学领域:

微生物学微生物学
疫苗学疫苗学疫苗学
流行病学流行病学

背景情况:

斯洛文尼亚从1999年到2016年主要使用带有动素 (PRN) 的非细胞性百日咳疫苗 (ACV).
转向缺乏PRN的ACV发生在2017年.
百日咳是由百日咳 Bordetella引起的,仍然是一个公共卫生问题.

研究的目的:

调查细胞性百日咳疫苗 (ACV) 成分变化的影响在Bordetella百日咳菌株上的影响.
为了确定斯洛文尼亚随着时间的推移,B. pertussis菌株缺乏性素 (PRN) 的流行率.

主要方法:

分析了2002年至2020年期间在斯洛文尼亚收集的123种Bordetella百日咳菌株.
在采集的菌株中,表达珀塔克丁 (PRN) 的基因型和/或表型特征.
PRN缺陷菌株流行率与疫苗接种政策变化的相关性.

主要成果:

在123个Bordetella pertussis菌株中,共有48个被确定为缺素 (PRN).
大多数PRN缺陷菌株 (44) 是在2017年之后收集的,这与PRN缺陷ACVs的引入相吻合.
在2017年后,观察到PRN缺乏B. pertussis菌株的显著增加.

结论:

在斯洛文尼亚引入缺乏性素 (PRN) 的非细胞性 pertussis 疫苗 (ACV) 与缺乏PRN的Bordetella pertussis菌株的增加有关.
细菌群体的这种转变可能会对百日咳疫苗的有效性和疾病流行病学产生影响.
对B. pertussis菌株的持续监测对于监测疫苗影响至关重要.

关键词:

百日咳 Bordetella 百日咳是一种疾病.斯洛文尼亚斯洛文尼亚斯洛文尼亚斯洛文尼亚没有细胞的百日咳疫苗疫苗.细菌细菌细菌是一种细菌.对于每一个人来说,这是一个巨大的变化.呼吸道感染呼吸道感染

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