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暴露于酸盐增塑剂会损害成年脊椎动物的正常大脑功能

Benedikt Maric¹, Stefan Schuster¹, Peter Machnik¹

¹University of Bayreuth, Department of Animal Physiology, Universitätsstraße 30, Bayreuth D-95440, Germany.

Ecotoxicology and environmental safety

|October 24, 2024

概括

暴露于常见的增塑剂二二乙甲酸盐 (DEHP) 和二甲酸盐 (DINP) 在环境相关的度显著损害成年脊椎动物的大脑功能,影响神经元通信和速度.

科学领域:

神经科学是一个神经科学.
环境毒理学环境毒理学
生态毒理学生态毒理学

背景情况:

酸盐是广泛使用的可塑化剂,具有已知的生殖和发育效应.
迪松尼尔甲酸盐 (DINP) 通常被认为是di-2-ethylhexyl甲酸盐 (DEHP) 的更安全替代品.
新出现的证据表明,DEHP可能会影响脊椎动物的血脑屏障,对大脑健康产生潜在影响.

研究的目的:

研究DEHP和DINP暴露对成年脊椎动物神经元功能的急性影响.
为了确定这些甲酸盐的环境相关度是否会影响基本的大脑功能.

主要方法:

在金鱼的毛特纳神经元上进行了体内细胞内记录.
金鱼被暴露在环境相关的DEHP或DINP度 (10μg/L或100μg/L) 中一个月.
分析的重点是感官输入,兴奋抑制平衡和神经元传导速度.

主要成果:

暴露于DEHP和DINP都改变了Mauthner神经元的感官输入.
甲酸暴露破坏了神经元激发和抑制之间的平衡.
莫特纳神经元的传导速度在暴露于任何一种甲酸盐后减少了20%.
即使在10μg/L的较低度下,也观察到显著的影响.

结论:

在环境相关水平上对DEHP和DINP的急性暴露会对成年脊椎动物的关键大脑功能产生负面影响.
这项研究强调了以前低估的脊椎动物大脑功能对甲酸盐暴露的敏感性.
这些发现表明,由于这些常见的塑化剂对环境的广泛污染,可能会对神经健康造成潜在风险.

关键词:

大脑功能大脑功能神经元功能的神经元功能甲酸是一种甲酸.塑料复合物塑料复合物塑化剂是一种可塑化剂.

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