在小鼠中,通过内质网膜应激通过脱氧尼瓦伦醇介导的损伤
Qingbo Zhao1, Siyi Zhang1, Weili Feng1
1Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming & Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Ecotoxicology and environmental safety
|October 24, 2024
概括
脱氧尼瓦伦醇 (DON) 通过诱导内质网膜 (ER) 应激和亡而导致损伤. 作为ER应激抑制剂的4-Phenylbutyric acid (4-PBA) 显示出对DON毒性的保护作用.
科学领域:
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 脱氧尼瓦伦醇 (DON) 是一种普遍存在的真菌毒素,具有重大健康风险.
- 损伤是与DON暴露相关的严重问题.
- 了解DON毒性的分子机制对于开发对策至关重要.
研究的目的:
- 为了研究DON诱导的损伤背后的分子机制.
- 评估内细胞网膜 (ER) 应激抑制对DON毒性的潜在保护作用.
主要方法:
- 建立了一个DON诱导的急性损伤小鼠模型.
- 组织学,生物化学和分子分析,包括西方斑点和RNA测序.
- 传输电子显微镜用于评估细胞超结构.
主要成果:
- DON暴露导致损伤,炎症,氧化应激和亡.
- 转录组分析显示,ER与压力相关的基因显著上调.
- DON诱导了ER和线粒体损伤,激活了未折叠的蛋白质反应 (UPR).
- 4-酸 (4-PBA) 治疗改善了DON诱导的ER压力,亡和组织损伤.
结论:
- 细胞内膜网膜 (ER) 的压力在DON诱导的损伤中起着至关重要的作用.
- 4-PBA通过减轻ER压力及其下游后果,对DON毒性产生保护作用.
关键词:
4 - 基酸是什么? 4-基酸是什么?脱氧尼瓦伦烯 (deoxynivalenol) 是一种除氧化烯 (deoxynivalenol) 的一种.细胞内膜网膜的压力应激小孩的伤害小孩的伤害毒性的毒性 毒性的毒性更多相关视频
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