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Updated: May 7, 2026

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在单分子水平上对转激素被活细胞吸收的定量分析

Marta Pilz1, Tomasz Kalwarczyk1, Krzysztof Burdzy2

  • 1Institute of Physical Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

Talanta
|October 24, 2024
PubMed
概括

本研究提出了一种使用多维时间相关单光子计数 (TCSPC) 来测量纳米药物吸收到细胞中的定量方法. 这一突破允许精确跟踪分子的进入,提高治疗交付效率的评估.

关键词:
光相关性光谱学光相关性光谱学细胞内分泌的量化研究定量成像技术的使用一个单细胞分析.

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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