全球对抗糖尿病药物诱导的肉症的负担:一项国际药监督研究
Jaehyun Kong1, Seoyoung Park2, Tae Hyeon Kim1
1Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Archives of gerontology and geriatrics
|October 24, 2024
概括
抗糖尿病药物与缩症有关,特别是SGLT2抑制剂. 然而,在这项研究中,葡萄糖类-1受体激活剂 (GLP-1 RAs) 没有显示出与肉类的显著关联.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 麻症对老年人来说是一个显著的健康风险,糖尿病是已知的促成因素.
- 新出现的证据表明,一种类型的抗糖尿病药物 - - 葡萄糖类-1受体激活剂 (GLP-1RAs) 可能与肉症的发展有关.
- 这项研究调查了sarcopenia和各种抗糖尿病药物类别之间的关系.
研究的目的:
- 通过使用药监数据,分析萨尔科佩尼亚和七种类型的抗糖尿病药物之间的联系.
- 为了确定哪些抗糖尿病药物类,如果有的话,与肉症有显著的关联.
- 具体评估GLP-1RA与肉症之间的潜在联系.
主要方法:
- 利用世界卫生组织国际药物监测数据库 (1967-2023年) 提供了超过1.31亿份报告.
- 分析报告的几率比率 (ROR) 和信息组件 (IC) 来评估药物-萨科佩尼亚关联.
- 对DPP-4抑制剂,GLP-1RA,胰岛素,甲胺,SGLT2抑制剂,硫尿素和 thiazolidinediones 的研究关联.
主要成果:
- 总体而言,抗糖尿病药物与肉症有显著的关联 (ROR 1.31).
- SGLT2 抑制剂与肉症的关联最强 (ROR 2.49),其次是甲胺 (ROR 1.86) 和 DPP-4 抑制剂 (ROR 1.67).
- 尽管报告的数量很高,GLP-1RA (n=93) 并没有显示出与肉类的统计学上显著的关联 (ROR 1.06).
结论:
- 作为一组,抗糖尿病药物显著与缩症的风险增加有关.
- 在评估的抗糖尿病药物类别中,SGLT2抑制剂具有最高的风险.
- 与一些担忧相反,GLP-1受体激动剂在这个大规模的药监测分析中没有发现与肉症有显著的关联.
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