向瘤转录因子c-myc通过寡核酸PROTAC用于治疗肝细胞癌

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Min Ai1, Hulin Ma1, Jianhua He1

  • 1Center for Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610064, China.

European journal of medicinal chemistry
|October 24, 2024
PubMed
概括

新型寡核酸蛋白溶解向仿真体 (PROTACs) 有效降解肝细胞癌 (HCC) 中的致癌性c-Myc蛋白. 这种有针对性的方法抑制了小鼠的瘤生长,为HCC提供了一个有希望的新治疗策略.

关键词:
肝细胞癌是肝细胞癌.有氧核酸的部分.这就是PROTAC.有针对性的治疗.c-Myccc 的意思是我的

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