孕妇的抑郁情绪和怀孕期间的血抗抑郁药治疗不同地塑造了胎儿-新生儿神经行为之间的连续性
Kayleigh S J Campbell1, Ursula Brain2, Gillian E Hanley1
1BC Children's Hospital Research Institute, Vancouver, Canada; Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver, Canada.
Early human development
|October 24, 2024
概括
产前暴露于血清素再吸收抑制剂 (SRIs) 或母亲抑郁症可能会改变胎儿的发育,影响新生儿的神经行为. 怀孕期间有效的心理健康管理对于积极的结果至关重要.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 神经发育生物学 神经发育生物学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 产前暴露于血清素再吸收抑制剂 (SRIs) 与新生儿的神经行为障碍有关.
- 目前尚不清楚这些干扰是否源于短暂的药理学效应或由于持续的妊娠期SRI暴露而改变的神经发育.
研究的目的:
- 为了研究第三个月的胎儿生理学和新生儿神经行为之间的纵向关系.
- 为了确定产前SRI或抑郁症暴露是否塑造了早期的神经行为连续性.
主要方法:
- 研究了127名孕妇及其后代,分为控制组,抑郁组 (无药),SRI-抑郁组和SRI-非抑郁组.
- 胎儿心率 (fHR) 多普勒测量,运动活动和血管血液动力学在怀孕36周时被评估.
- 新生儿的神经行为成熟度在出生后的第7天被评估,分析使用部分最小平方和等级回归.
主要成果:
- 两个维度解释了胎儿和新生儿测量之间的74%的协差.
- 较低的fHR可变性和更大的fHR减速预测SRI抑郁新生儿的警觉性较低.
- 较低的胎儿脑血管抵抗预测了抑郁的新生儿的较低的运动分数;对euthymia的SRI治疗没有与障碍相关.
结论:
- 孕产妇抑郁症,无论是无药或SRI治疗的持续症状,都会对胎儿-新生儿的神经行为连续性产生不同的影响.
- 神经行为障碍可能起源于出生前.
- 怀孕期间有效的心理健康管理至关重要.
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