一个Burkholderia污染物在重症监护室的爆发与受污染的浴溶液有关:控制和微生物学的发现
Daniela Kallíope de Sá Paraskevopoulos1, Carlos Henrique Camargo2, Priscila Koba Kodato1
1Infection Control Department, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.
American journal of infection control
|October 24, 2024
概括
在ICU中爆发的Burkholderia cepacia复杂疫情被追溯到无冲洗洗液 (NRBS). 全基因组测序 (WGS) 确定了来源为Burkholderia污染物的特定克隆.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 作为非无菌溶液中的污染物,Burkholderia cepacia复合物 (BCC) 构成重大威胁.
- 一个重症监护室 (ICU) 经历了与无冲洗洗液 (NRBS) 相关的爆发.
研究的目的:
- 在ICU中调查BCC爆发的来源和特征.
- 确定NRBS在BCC传输中的作用.
主要方法:
- 患者病例分析患者病例分析
- 环境采样环境采样
- 实验室对分离物进行鉴定.
- 脉冲场凝电泳 (PFGE) 是一种电泳技术.
- 全基因组测序 (WGS) 是一种全基因组测序.
主要成果:
- 调查了32个病例和16个分离物,被确定为Burkholderia污染物.
- 确定了两个不同的克隆:ST2175 (在患者和浴中发现) 和ST762.
- 确认NRBS是爆发的来源,与B. contaminans.的ST762克隆有关.
结论:
- 早期怀疑共同来源和快速控制措施对于疫情管理至关重要.
- 全基因组测序 (WGS) 是细菌类型和环境污染调查的重要工具.
- 对水性产品的监管是必要的,以防止未来的疫情爆发.
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