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间歇性与持续的卡路里限制相比,用于治疗与代谢功能障碍相关的脂肪性肝病:一项随机临床试验
Xiaoyang Sun1, Fan Li2, Hongmei Yan1
1Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Metabolic Disease, Fudan University, Shanghai, China.
The American journal of clinical nutrition
|October 24, 2024
概括
间歇性卡路里限制 (ICR) 和持续性卡路里限制 (CCR) 在MASLD患者中同样降低了肝脂肪. ICR 5:2饮食为MASLD治疗提供了可行的替代方案,并显示出高度的坚持.
科学领域:
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
- 饮食干预 饮食干预
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响肝脏健康.
- 卡路里限制对MASLD是有效的,但面临着坚持挑战.
- 调查像间歇性卡路里限制 (ICR) 这样的替代饮食策略至关重要.
研究的目的:
- 为了比较间歇性卡路里限制 (ICR) 与持续卡路里限制 (CCR) 在治疗MASLD的疗效.
- 评估ICR和CCR对肝脂肪含量和其他代谢标记物的影响.
- 评估两种饮食方法的坚持率.
主要方法:
- 一个为期12周的平行手臂随机对照试验,涉及60名患有MASLD的成年人.
- 参与者被分配到ICR (2禁食日/周) 或CCR.
- 使用1H-质子磁共振光谱测量肝脏脂肪含量 (LFC).
主要成果:
- 两组ICR和CCR都显示了LFC的显著减少,它们之间没有统计学上显著的差异.
- 国际血清测试显示,脂肪质量和糖化血红蛋白减少的趋势更大.
- 在ICR和CCR组中都观察到很高的坚持.
结论:
- 间歇性卡路里限制 (ICR) 和持续性卡路里限制 (CCR) 在减少MASLD中的肝脂肪含量方面表现出相似的有效性.
- ICR 5:2饮食为MASLD管理提供了一个有希望和高度坚持的替代方案.
- 进一步的研究可能会探索ICR对身体组成和血糖控制的具体益处.
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