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使用脉冲振荡计系统的肺功能和在4岁时的临床结果,在极度早产的儿童中,有或没有支气管肺形
Celine Delestrain1, Kamel Halitim2, Manon Tauzin3
1Centre Hospitalier Intercommunal de Créteil, Service de Pédiatrie Générale, Créteil, 94000, France; Centre des Maladies Respiratoires Rares (RESPIRARE®), CRCM, Créteil, France; University Paris Est Créteil, INSERM, IMRB, 94010, Créteil, France; FHU SENEC, Créteil, France.
Respiratory medicine
|October 24, 2024
概括
大多数极度早产的孩子在4岁时有异常的呼吸道阻力,不论是支气管肺功能障碍症 (BPD). 使用脉冲振荡计的早期肺功能评估对于监测这些高风险婴儿至关重要.
科学领域:
- 儿科肺病学 儿科肺病学
- 新生儿科学 新生儿科学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 极度早产的婴儿面临呼吸道并发症的重大风险.
- 支气管肺功能障碍症 (BPD) 是一种常见的并发症,影响这些婴儿的肺部发育.
- 早期发现肺功能缺陷对于及时干预至关重要.
研究的目的:
- 评估极度早产儿的早期肺功能和呼吸道疾病.
- 为了比较患有BPD和没有BPD的极度早产儿之间的肺功能.
- 评估脉冲振荡计对于早期检测呼吸系统异常的有用性.
主要方法:
- 对28周妊娠期出生婴儿的前性研究.
- 肺功能 (脉冲振荡计),呼吸道发病率和4年后评估的生长.
- 在患有BPD和没有BPD的儿童之间比较肺功能参数 (耐力,反应率).
主要成果:
- 76%的极度早产儿在4岁时表现出升高的呼吸阻力 (R5),不论其BPD状态如何.
- 在BPD和非BPD组之间没有发现抗性 (R5,R20) 或反应力 (X5) 的显著差异.
- 在该队列中,喘症状普遍存在 (30%),独立于BPD.
- 支气管扩展剂治疗没有显著改变抗药性测量.
结论:
- 脉冲振荡计揭示了在学前儿童中广泛存在的异常呼吸道阻力,这些儿童出生时极其早产.
- 肺功能缺陷在这个人群中很常见,即使没有BPD病史.
- 脉冲振荡计是非常早产婴儿早期肺功能评估的一个有价值的工具.
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