跨膜超声波刺激中的参数和效应之间的关系
Tulika Nandi1, Benjamin R Kop2, Kim Butts Pauly3
1Donders Institute for Brain Cognition and Behaviour, Radboud University, Thomas van Aquinostraat 4, 6525 GD, Nijmegen, the Netherlands; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, the Netherlands.
Brain stimulation
|October 24, 2024
概括
优化人类神经调节的跨超声波刺激 (TUS) 需要仔细的参数选择. 研究表明,较低的频率,更高的强度和更长的持续时间产生更大的效果,但在翻译研究结果时建议谨慎.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 医学物理 医学物理
背景情况:
- 超超声波刺激 (TUS) 是一种新兴的人类神经调节的非侵入性技术.
- 建立最佳的TUS协议对于最大限度地提高其治疗和研究效率至关重要.
- 目前对TUS参数-结果关系的理解需要综合和批判性评估.
研究的目的:
- 审查和综合实证证据,将可调节的TUS参数与体外和体内结果联系起来.
- 为TUS研究人员提供指导,帮助他们做出关于最佳参数设置的明智决策.
- 为未来的TUS干预确定协议翻译和参数推断中的挑战.
主要方法:
- 系统地汇总和检查有关TUS参数及其影响的现有经验数据.
- 综合体内和体内研究的结果的多尺度分析.
- 讨论跨模型协议翻译和TUS-大脑相互作用中的挑战.
主要成果:
- 经验证据表明,较低的MHz以下频率,更高的强度/压力和更长的脉冲持续时间增强了TUS效应.
- 综合表明,通过特定的参数调整,神经调节效率更高的潜力.
- 在直接推断不同实验范式的发现方面存在重大挑战.
结论:
- 精细的TUS参数,由这种合成告知,可以推进人类神经调节.
- 谨慎地解释各种实验数据是开发强大的TUS协议所必需的.
- 需要进一步的研究来克服翻译TUS协议和理解大脑相互作用的挑战.
相关概念视频
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When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high pressures...