含有Wolfiporia cocos聚糖的益生菌粉通过调节免疫活动和肠道微生物群来缓解与抗生素相关的腹
Jing Tang1, Xiaojun Ma2, Xinling Song3
1College of Food Engineering, Qingdao Institute of Technology, Qingdao, Shandong 266000, China.
沃尔菲波利亚可可斯多糖 (WP) 增强了益生菌的生存和免疫功能. 带有WP (PWP) 的益生菌粉有效调节肠道微生物群,并减轻小鼠的抗生素相关腹.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 软化益生菌需要保护剂来保持生存能力和有效性.
- 沃尔菲波利亚可可斯多糖 (WP) 被研究为益生菌的新型保护剂.
研究的目的:
- 评估WP作为益生菌的冷化保护剂.
- 在抗生素相关腹 (AAD) 鼠标模型中评估WP增强益生菌粉 (PWP) 的免疫调节和肠道微生物群调节作用.
主要方法:
- 对七种多糖的选,以确定最佳的冷解保护剂.
- 优化WP剂量和最大益生菌生存率的比例.
- 向AAD小鼠注射PWP并评估免疫参数 (IgM,IgG,IgA,巨细胞活动) 和肠道微生物群组成.
主要成果:
- WP显著增加了益生菌的存活率,在最佳条件下,存活率为83.06%.
- 与单独使用益生菌相比,PWP显示出优异的免疫调节作用,增加IgM,IgG,IgA和巨细胞活性.
- 在AAD小鼠中,PWP有效地恢复了肠道微生物群的稳态,调节了蛋白质细菌 (Sutterella) 和细菌群 (Muribaculaceae) 的水平.
结论:
- WP是益生菌的有效冷解保护剂,增强其生存和免疫调节性质.
- 通过调节肠道微生物群和调节免疫反应,PWP可以缓解与抗生素相关的腹.
- WP有望开发具有改善治疗结果的先进益生菌配方.
更多相关视频
03:25Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
Published on: December 27, 2024
05:41Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
相关概念视频
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Irritable Bowel Syndrome III: Medical and Nursing Management
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
