微晶纤维素和伊塔康酸 pH 敏感的半透网络水凝用于口服胰岛素输送
Harish Kumar Chaudhary1, Priyanka Singh2, Karishma Niveria2
1Department of Chemistry, Dyal Singh College, University of Delhi, 110003 New Delhi, India.
International journal of biological macromolecules
|October 24, 2024
概括
研究人员开发了一种用于口服胰岛素输送的新型水凝,改善了患者的服从性. 这种微晶纤维素和伊塔康酸水凝对有效的糖尿病管理有很大的希望.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病是一种重大的全球健康挑战.
- 目前的皮下胰岛素输送方法患有低患者合规性.
- 开发有效的口服胰岛素输送系统对于糖尿病管理至关重要.
研究的目的:
- 合成和描述用于口服胰岛素输送的新型水凝.
- 为了评估pH敏感的胀行为和水凝的胰岛素释放特性.
- 评估水凝作为口服胰岛素输送载体的体内疗效.
主要方法:
- 使用微晶纤维素和伊塔康酸的自由基聚合制造水凝,用N,N'-甲基基烯胺 (NNMBA) 作为交叉连接剂.
- 在蒸水,盐水,葡萄糖溶液和各种pH值中进行了胀研究.
- 材料的特征包括扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR) 和热重力测量分析 (TGA).
- 使用布拉德福德试验量化了体外胰岛素释放,并在雄性Wistar大鼠身上进行了体内研究.
主要成果:
- 合成的pH敏感水凝呈现出显著的胀,在蒸水中达到20.38g/g.
- 与盐水相比,在葡萄糖溶液中观察到增强的胀,在性和酸性条件下出现更高的胀.
- SEM证实了多孔结构,FTIR证实了化学成分,TGA表明了热稳定性.
- 在体外和体内研究表明,水凝的潜力作为一个有效的载体,用于口服胰岛素的交付.
结论:
- 开发的微晶纤维素-伊塔康酸水凝是口服胰岛素输送的有希望的候选者.
- 它的pH敏感膨胀和体内有效性证明支持其在糖尿病管理中改善患者遵守的潜力.
- 这种水凝代表了开发替代胰岛素注射途径的重大进展.
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