脑卒中后焦虑的患病率及其与全球认知障碍的关联:个人参与者数据分析
Florine Ruthmann1, Jessica W Lo2, Anne-Marie Mendyk-Bordet1
1Lille Neuroscience et Cognition, Degenerative and Vascular Cognitive Disorders Team, UMR-S 1172, INSERM, Lille F-59000, France.
Journal of affective disorders
|October 24, 2024
概括
在中风后,焦虑是很常见的,影响到35%的患者,特别是女性. 脑卒中后焦虑与抑郁症和认知障碍有关,突出了干预的关键领域.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 焦虑是中风后经常出现的疾病.
- 脑卒中后焦虑 (PSA) 的决定因素尚未得到充分了解.
- 缺血性中风患者在事件发生后3-6个月内会出现焦虑.
研究的目的:
- 评估中风后焦虑症 (PSA) 的患病率.
- 在缺血性中风幸存者中识别PSA的相关物.
- 在中风后3-6个月内分析与PSA相关的因素.
主要方法:
- 利用了三项STROKOG联盟队列研究的数据.
- 标准化的人口和临床数据收集.
- 采用了两步的个人参与者数据 (IPD) 分析来识别PSA相关物.
- 使用标准化库存和标准评估PSA,中风后抑郁症 (PSD) 和中风后认知障碍 (PSCI).
主要成果:
- 包括584名患者;整体PSA患病率为35%.
- 焦虑患者更有可能是女性,受教育程度较低,并经历较高的中风严重程度.
- PSA与PSD (χ2 = 118.09,p < 0.001) 和PSCI (χ2 = 23.81,p < 0.001) 有意义地相关.
- 患有PSCI的患者出现PSA的几率增加 (OR = 1.84,95%CI = [1.14; 2.91]).
结论:
- 在缺血性中风后,焦虑是常见的结果.
- 女性性别,抑郁症和认知障碍是PSA的显著相关物.
- 这些发现强调了对中风幸存者的查和焦虑管理的需要,特别是在风险人群中.
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