在患有强迫症患者中,默认模式网络子系统的静止状态功能连接性减少
Qihui Guo1, Rongrong Zhu1, Huixia Zhou1
1Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Journal of affective disorders
|October 24, 2024
概括
在默认模式网络的核心子系统中,静止状态功能连接 (rsFC) 的减少是强迫症 (OCD) 的关键特征. 这种异常与痴迷的严重程度相关,并且可能受到药物的影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 强迫症 (OCD) 与默认模式网络 (DMN) 的异常有关,这是一个关键的大脑网络.
- 之前的神经成像研究表明,在强迫症患者中,DMN静止状态功能连接 (rsFC) 的发现不一致.
- 该DMN包括三个子系统:核心,背部中部前额叶皮层 (dMPFC) 和中部叶 (MTL).
研究的目的:
- 调查强迫症患者在DMN子系统内和之间rsFC的变化.
- 为了检查DMN rsFC异常和强迫症症状严重程度之间的关系.
- 探索药物对强迫症DMN rsFC的潜在影响.
主要方法:
- 招募了39名强迫症患者和45名健康对照 (HC).
- 评估了使用耶鲁-布朗强迫症尺度 (YBOCS) 的强迫症症状严重程度.
- 使用种子对种子方法在DMN子系统内和之间计算rsFC强度.
主要成果:
- 与HC相比,强迫症患者在DMN核心子系统内显著降低了rsFC强度.
- 这种减少在未服用药物的强迫症患者中是显而易见的,但在服用药物的患者中并非如此.
- 减少核心子系统 rsFC 的强度与强迫症组的强迫症严重程度负相关,特别是在未服用药物的个体中.
结论:
- 在DMN核心子系统内减少rsFC强度是强迫症的特征发现.
- 这种rsFC变化可能成为强迫症痴迷严重程度的潜在生物标志物.
- 药物治疗可能会影响强迫症患者的DMN rsFC强度.
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