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韩国首次和第二次复发骨质疏松性骨折的迫在眉的风险

Miryoung Kim¹, Hyun-Jin Han², Donghyun Pyun²

¹College of Pharmacy, Pusan National University, Busan, Republic of Korea; College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea; Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul, Republic of Korea.

|October 24, 2024

概括

患有骨质疏松性骨折 (OFs) 的患者面临更高的后续骨折风险. 在韩国,第二次复发OF的风险明显高于第一次,需要针对风险人群制定有针对性的治疗策略.

科学领域:

老年学和老年医学是老年学和老年医学.
整形外科手术整形外科手术
公共卫生公共卫生

背景情况:

骨折史增加了随后和次要骨折的风险.
全球指导方针提倡主动药物治疗,以预防骨折,在患有骨质疏松性骨折 (OF) 迫在眉的风险的患者.
关于韩国人口中OFs迫在眉的风险的研究有限.

研究的目的:

评估韩国患者中第一和第二次复发性骨质疏松性骨折 (OF) 的迫在眉风险.
确定影响反复性OFs风险的人口因素.

主要方法:

韩国医疗保险审查和评估数据库 (2012-2017) 的回顾性分析.
包括55岁以上的患者在2013年具有OF指数 (部/股骨,脊椎,手腕,半径,部/骨,脚).
使用多变量Cox比例危险回归,评估首次复发的OF发病率在OF指数后2年内和第二次复发的OF发病率在首次复发的OF后2年内.

主要成果:

大约17%的患者在2年内经历了第一次复发的OF;28%的患者在2年内经历了第二次复发的OF.
第二次复发性OF的两年发病率 (22.0/100人年) 比第一次复发性OF (9.6/100人年) 高.
与男性相比,女性的第一次 (HR=1.31) 和第二次 (HR=1.43) 复发性OF风险显著更高.

结论:

在韩国,第二次复发骨质疏松性骨折 (OF) 的迫在眉风险大于第一次复发OF的风险.
鉴于随着每次后续骨折的风险不断升级,针对性治疗对于经历第一次复发的OF患者至关重要.
这项研究强调了韩国需要加强骨折预防策略的必要性,特别是在女性和有骨折病史的人群中.

关键词:

骨折,骨头骨折,骨头骨折,骨骨折,骨骨折,骨骨折,骨骨折,骨骨折,骨骨折,骨骨折,骨骨折,骨骨折.骨质疏松症的结构经常发生的骨折.随后的骨折是随后的骨折.

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