预防和管理德诺苏马布的停止反弹骨折的预防和管理
1Division of Endocrinology, Department of Medicine, Rush University Medical Center, 1725 West Harrison Street Suite 250, Chicago, IL 60612, USA.
Endocrinology and metabolism clinics of North America
|October 24, 2024
概括
停止使用登苏马布可以导致14分之一的患者因过度骨再吸收而出现反弹骨折. 德诺苏马布后的快速连续治疗显著降低了这种风险,并改善了患者的治疗结果.
科学领域:
- 骨生物学和药理学 骨生物学和药理学
- 骨质疏松症的管理
- 临床内分泌学 临床内分泌学
背景情况:
- 德诺苏马布是一种用于治疗骨质疏松症和其他骨疾病的单克隆抗体.
- 停止使用登苏马布可以导致骨吸收的快速增加,称为登苏马布效应.
- 在停止服用德诺苏马布后,反弹相关的骨折是一个重大问题.
研究的目的:
- 总结一下代诺苏马布反弹相关骨折的现象.
- 为了突出与没有连续治疗停止使用德诺苏马布相关的骨折和死亡风险增加.
- 强调顺序抗吸收疗法在减轻这些风险方面的有效性.
主要方法:
- 对现有文献和关于德诺苏马布治疗和停止治疗的回顾性研究的审查.
- 对患者中断denosumab治疗时的骨折发生率和死亡率的分析.
- 对顺序抗吸收疗法对骨折风险的影响的评估.
主要成果:
- 大约每14名患者中就有1名在没有顺序治疗的情况下停止使用denosumab后出现反弹相关骨折.
- 延迟使用德诺苏马布剂量 (平均>7个月) 或在没有连续治疗的情况下停止使用与死亡率的增加有关.
- 多次连续的药物治疗方案已经显示出反弹脊椎骨折的大幅减少.
结论:
- 德诺苏马布反弹相关骨折是影响多个患者群体的临床显著事件.
- 停止使用登苏马布需要谨慎管理,并进行连续的抗吸收疗法,以防止骨过度吸收和骨折.
- 实施适当的顺序治疗对于改善患者的生活质量和降低德诺苏马布治疗后死亡风险至关重要.
关键词:
延迟的代诺苏马布剂量停止使用德诺苏马布.德诺苏马布的退出情况骨质疏松症是一种骨质疏松症.与骨质疏松症相关的死亡率普罗利亚 普罗利亚 是一个类型.与反弹相关的脊椎骨折 (RAVF)序列疗法是一种序列疗法.更多相关视频
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