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非手术脊髓梗塞:病例系列和功能性结果的长期随访

Fionán McBride1, Jane Anketell2, Gavin V McDonnell3

  • 1Queen's University Belfast, Belfast, N.Ireland, UK. fionanmcbride01@gmail.com.

Spinal cord series and cases
|October 25, 2024
PubMed
概括

脊髓梗塞很少发生,但很严重. 早期诊断和治疗至关重要,尽管脊髓梗塞的长期恢复往往是有限的,反映了最初的呈现严重程度.

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...