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Updated: Jun 9, 2025

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
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逐步酸化和SUMOylation的PIDD1驱动PIDDosome组装作为对DNA修复失败的反应

Richa B Shah1,2, Yuanyuan Li1,2, Honglin Yu1,2

  • 1Department of Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nature communications
|October 25, 2024
PubMed
概括

SUMOylation通过调节DNA损伤后的PIDDosome形成来控制编程细胞死亡. 这一过程对于消除未经修复的DNA跨链交叉链接的细胞至关重要.

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