通过潜在的炎症途径,EDNRA会影响对大动脉动脉样硬化中风的易感性
Zhiyao Xu1, Qiang Zhou1, Cao Liu2
1Department of Neurology, The Affiliated Hospital of Southwest Jiaotong University and The Third People's Hospital of Chengdu, No. 82, Qinglong Street, Qingyang District, Chengdu, Sichuan, China.
Scientific reports
|October 25, 2024
概括
末端素A型受体 (EDNRA) 的遗传变异与大动脉动脉硬化性中风 (LAA) 的风险增加有关. 这种关联可能涉及NLRP3炎症途径,这表明LAA的潜在治疗点.
科学领域:
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
- 心血管研究研究心血管研究
背景情况:
- 大动脉动脉硬化性中风 (LAA) 是一个重大的健康问题.
- 结尾素A型受体 (EDNRA) 基因多态性对LAA敏感性的作用尚未完全理解.
- 炎症与动脉样硬化和中风的发病有关.
研究的目的:
- 调查汉族中国人群中EDNRA遗传多态和LAA风险之间的关联.
- 探索炎症的参与,特别是NLRP3通路,在这个协会中.
- 分析EDNRA基因表达,炎症标志物和LAA之间的相关性.
主要方法:
- 在EDNRA中使用病例控制关联分析对16个单核酸多态 (SNPs) 的基因定型.
- 量化EDNRA和NLRP3的mRNA和蛋白质水平.
- 在周围血液中测量炎症性细胞因子度 (TNFα,IL-1β,IL-6,IL-10,IL-18,CCL18).
- 对SNP,基因表达和炎症标志物之间的相关性分析.
主要成果:
- EDNRA的rs5343 TT基因型与LAA的风险增加显著相关 (OR=3.243,P=0.001).
- 与对照组相比,在LAA患者中观察到NLRP3上调和IL-10,IL-18和CCL-18的升高水平.
- 与NLRP3,IL-6,IL-10和IL-18水平相关的EDNRA多态.
- 在EDNRA转录和NLRP3转录水平 (r=0.437,p<0.001) 和IL-18度 (r=0.212,p<0.001) 之间发现了正相关性.
结论:
- EDNRA遗传变异与对大动脉动脉硬化性中风的易感性有关.
- NLRP3介导的炎症途径可能有助于EDNRA和LAA之间的关联.
- 这些发现突出了EDNRA作为LAA的潜在遗传因素和治疗目标.
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