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一个RNA-seq数据规范化方法的基准,用于在人类基因组规模的代谢网络上进行转录组映射.

Hatice Büşra Lüleci1, Dilara Uzuner1, Müberra Fatma Cesur1

  • 1Department of Bioengineering, Gebze Technical University, Kocaeli, 41400, Turkey.

NPJ systems biology and applications
|October 25, 2024
PubMed
概括

选择正确的RNA-seq规范化方法对于使用iMAT和INIT等算法创建准确的特定条件代谢模型至关重要. 样本间正常化方法 (RLE,TMM,GeTMM) 为与疾病相关的基因提供了更好的预测准确性.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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