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Updated: Jun 9, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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一个具有结构信息的人类蛋白质-蛋白质相互作用体揭示了由疾病突变引起的全蛋白质体乱

Dapeng Xiong1,2,3, Yunguang Qiu4,5, Junfei Zhao6

  • 1Department of Computational Biology, Cornell University, Ithaca, NY, USA.

Nature biotechnology
|October 25, 2024
PubMed
概括

我们开发了PIONEER,这是一种深度学习工具,可以预测蛋白质-蛋白质接口,以了解疾病. 开拓者通过分析蛋白质相互作用来识别疾病突变,并帮助精准医学.

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