在出生时体重非常低的婴儿中,耐火性呼吸困扰综合征的危险因素
Jeongmin Shin1, Chang Won Choi2,3, Byung Kook Lee4
1Department of Pediatrics, Seoul St. Mary's Hospital, Seoul, 06591, Republic of Korea.
BMC pediatrics
|October 25, 2024
概括
孕产妇高血压障碍是非常低出生体重婴儿中耐火性呼吸系统应急综合征 (RDS) 的关键风险因素. 耐火性RDS与更糟糕的新生儿结局和增加的死亡率有关.
科学领域:
- 新生儿医学 新生儿医学
- 周围生理学 周围生理学
- 儿科重症监护 儿科重症监护
背景情况:
- 呼吸困难综合征 (RDS) 是非常低出生体重婴儿 (VLBWI) 的常见并发症.
- 耐火RDS需要多次表面活性剂处理,这带来了重大管理挑战.
研究的目的:
- 确定与VLBWIs中耐火RDS相关的围产期风险因素.
- 了解耐火RDS对新生儿发病率和死亡率的影响.
主要方法:
- 韩国新生儿网络 (KNN) 对2013年至2020年间出生的VLBWI的数据分析.
- 排除在5天内死亡或没有接受表面活性剂的婴儿.
- 将RDS分为响应良好 (一次表面活性剂剂量) 和耐火 (≥2剂表面活性剂剂量) 的RDS组.
- 多变量逻辑回归以确定围产期特征与耐火RDS之间的关联.
主要成果:
- 低妊娠年龄,男性性别,剖腹产,孕产妇高血压障碍和低的5分钟Apgar分数是耐火性RDS的重要危险因素.
- 产前皮质类固醇使用和母体胆膜炎与耐火性RDS相反相关.
- 耐火性RDS显着与新生儿主要发病率和死亡率的增加有关.
结论:
- 孕产妇高血压障碍是耐火性RDS的一个重要危险因素.
- 耐火性RDS与新生儿不良结果有关,包括较高的发病率和死亡率.
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