对神经退行性疾病的环境大气风险因素的地理空间分析:系统性审查更新
Mariana Oliveira1,2, André Padrão3, Ana Cláudia Teodoro4,5
1Center for Health Technology and Services Research (CINTESIS@RISE), Faculty of Medicine, University of Porto, Rua Doutor Plácido da Costa, s/n, Porto, 4200-450, Portugal. mariana_ramos_oliveira@hotmail.com.
Systematic reviews
|October 25, 2024
概括
这份更新的综述强调了神经退行性疾病的主要环境风险因素,并指出了对空气污染物如PM2.5和NO2的关注,以及在地理分析中越来越多地使用遥感.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 之前对神经退行性疾病环境风险因素的系统审查需要由于新研究而进行更新.
- 了解环境暴露的不断变化的情景及其与神经退行性疾病的地理关联至关重要.
研究的目的:
- 更新与神经退行性疾病相关的环境风险因素的证据.
- 分析用于研究这些协会的地理方法.
- 自从之前的审查以来,追踪重点疾病和环境因素的转变.
主要方法:
- 在PubMed,科学网和Scopus (2020年2月至2023年2月) 进行了系统的文献搜索.
- 纳入标准侧重于结合神经退行性疾病,环境大气因素和地理分析的研究.
- 关键字和搜索术语反映了原始评论中的关键字和搜索术语,以便进行一致的比较.
主要成果:
- 痴呆症,包括阿尔茨海默氏症,是研究最多的疾病 (60.0%),在之前的审查中从多发性硬化症转移.
- 颗粒物 (PM2.5) 和二氧化 (NO2) 成为主要的环境污染物 (分别为65.7%和42.9%的新研究).
- 患者居住地仍然是主要的地理方法 (82.9%),远程传感在环境变量计算方面获得了显著的吸引力 (45.7%).
结论:
- 该领域的研究重点是空气污染物,并利用遥感来评估环境暴露的研究显著增加.
- 痴呆症和阿尔茨海默病现在是与环境因素有关的主要神经退行性疾病.
- 需要继续进行研究,以阐明环境暴露,地理和神经退行之间的复杂相互作用.
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