用抗甲原化合物3-NOP编程小牛的小肠微生物组发育
Gonzalo Martinez-Fernandez1, Stuart E Denman1, Nicola Walker2
1CSIRO, Agriculture and Food, Queensland Bioscience Precinct, St. Lucia, Qld, Australia.
Animal microbiome
|October 25, 2024
概括
在小牛的早期生活中,3-NOP (3-nitrooxypropanol) 补充剂减少了甲排放,建立了持久的小牛肠微生物组. 这种早期干预影响了微生物的结构和功能,在治疗停止后很长一段时间.
科学领域:
- 动物营养和微生物学
- 动物科学和环境影响
- 甲减排战略 甲减排策略
背景情况:
- 体微生物组在宿主消化和温室气体排放中起着至关重要的作用.
- 3-氧醇 (3-NOP) 是一种抗甲原化合物,具有降低甲的潜力.
- 了解青春期的发育和干预措施的影响对于可持续的畜牧业至关重要.
研究的目的:
- 为了研究母体和后代的3-NOP补充剂对肠微生物和发酵概况的影响.
- 评估早期3-NOP干预对乳头微生物组结构和功能的持续影响,直到12个月大.
- 为了评估甲排放与3 - NOP撤销后的反肠微生物变化有关.
主要方法:
- 48只怀孕的母牛及其后代被分配到四个组:对照 (-) 或母牛和小牛的3-NOP (+).
- 治疗时间从分娩前6周到断奶;后代监测到12个月.
- 进行了液分析,甲测量 (Greenfeed系统) 和微生物种群分析.
主要成果:
- 3-NOP处理将乳头发酵从酸转移到酸,增加分支链脂肪酸和酸.
- 微生物变化包括甲基生物的减少和Succiniclasticum spp.的增加,Candidatus Saccharimonas,Fibrobacter,Prevotellaceae,Succinivibrioacea和Entodinium.这些微生物的变化包括甲基生物的减少和Succiniclasticum spp.的增加.
- 早期的3-NOP干预表明,在断奶后的28周内,对乳头的微生物结构产生持久的影响,其中一组的甲排放量减少了15%.
结论:
- 早期的3-NOP干预可以建立一个类似于低甲成年人的乳头微生物组,在断奶前的微生物构成年龄微生物组的65%.
- 停止使用后,3-NOP的抗甲原效应减弱,突出显示需要优化剂量和时间来持续减少甲.
- 需要进一步的研究来确定最佳的3-NOP策略,以在各种条件下持续减少小牛的甲排放.
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