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芳酶,,TMPRSS2:COVID-19严重程度的决定因素
Eric C Mohan1, Jude P J Savarraj2, Gabriela D Colpo1
1Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.
Biology of sex differences
|October 25, 2024
概括
高水平的芳酶和跨膜蛋白酶血清2 (TMPRSS2) 与男性的COVID-19严重程度和死亡风险增加相关. 这些发现突出了改善住院COVID-19患者治疗结果的潜在治疗目标.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 男性的性别是严重的COVID-19结果的已知风险因素,可能与性激素有关.
- 雄激素会影响跨膜蛋白酶血清2 (TMPRSS2) 的表达,这是SARS-CoV-2进入的关键蛋白质.
- 芳酶将雄激素转化为雌激素,而雌激素可能具有保护作用.
研究的目的:
- 在住院COVID-19患者中测量芳酶,,雌激素和TMPRSS-2的血度.
- 阐明COVID-19中与性别相关的差异的动态.
- 为了将这些标记与疾病严重程度和死亡率相关联.
主要方法:
- 对265名住院COVID-19患者进行前性队列研究.
- 用ELISA测量的,芳酶,TMPRSS-2和雌激素的血水平.
- 根据疾病严重程度分层的患者 (中度重度与关键);使用曼·惠特尼大学和后勤回归的统计分析.
主要成果:
- 与女性相比,男性的TMPRSS2和丸激素水平显著更高.
- 在COVID-19严重程度增加的患者中,TMPRSS2和芳酶水平较高,而丸激素水平较低.
- 较高的芳酶和TMPRSS-2水平与非幸存者的死亡率有显著的关联.
结论:
- ,芳酶和TMPRSS2是COVID-19严重程度的重要标志物.
- 雌醇水平与疾病严重程度没有相关性.
- 增加的芳酶和TMPRSS-2水平可以预测住院COVID-19患者的死亡率.
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