相关实验视频

Updated: Jun 9, 2025

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.0K

化学遗传神经元沉默将c-Jun激活从皮质的细胞死亡解

Caleb A Wood1, Preethi Somasundaram2, Jacob M Dundee1

  • 1Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.

The European journal of neuroscience
|October 25, 2024
PubMed
概括

脑内神经元的电静止会激活c-Jun通路,但这种反应并不能防止神经退行. 像综合应激反应这样的替代机制,可能会在早期阿尔茨海默病中驱动细胞死亡.

关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.甘油ClCl 的使用方法化学遗传沉默是一种沉默.c- 六月 月 日.内皮层 (entorhinal cortex) 是一个内侧的皮层.选择性神经元脆弱性的选择性神经元脆弱性

更多相关视频

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c07:42

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Published on: June 29, 2011

17.4K
A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning09:22

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning

Published on: June 22, 2015

14.6K

相关概念视频

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.2K