在头部和部状细胞癌中小核核RNAs
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Journal of dental research
|October 25, 2024
概括
小核RNAs (snoRNAs) 在头部和部状细胞癌 (HNSCC) 中表达变化,影响瘤进展. 一些snoRNAs促进癌症,而另一些则可能提供保护作用,这表明在HNSCC中具有潜在的诊断和治疗作用.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 在瘤学瘤学.
背景情况:
- 小核RNAs (snoRNAs) 是非编码RNAs,通常是内部的,具有多样化的结构.
- 失调的snoRNA表达在各种人类恶性瘤中被观察到,包括头部和部状细胞癌 (HNSCC).
- 高通量测序已经在HNSCC组织中确定了许多差异表达的snoRNA.
研究的目的:
- 审查snoRNAs在HNSCC进展中的结构,表达特征和作用.
- 探索snoRNAs作为HNSCC管理的诊断和治疗点的潜力.
主要方法:
- 使用高通量测序对HNSCC队伍中snoRNA表达特征的分析.
- 审查有关snoRNA功能和HNSCC致癌机制的现有文献.
- 在体外和体内研究,调查snoRNA及其宿主基因的功能作用.
主要成果:
- 在567个HNSCC队列中,在1524个snoRNA基因中,有113个被发现与生存有关.
- 调节后的snoRNAs通过激活瘤基因或Wnt/β-catenin通路来促进HNSCC,增强瘤细胞活力和迁移.
- 对宿主基因的破坏抑制了Wnt/β-catenin信号传递,并在体内抑制了瘤的生长.
- 四种snoRNA被降低调节,其中SNORA36B和U3可能充当保护因素.
结论:
- 失调的snoRNAs是HNSCC致癌和发展的组成部分.
- 斯诺RNAs通过类似微RNA的活动和替代拼接的调节来发挥其功能.
- 对snoRNA表达和功能的进一步研究可能会为HNSCC.产生新的诊断和治疗策略.
相关概念视频
The Nucleolus
8.7K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.7K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K
siRNA - Small Interfering RNAs
16.6K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.6K
Small GTPases - Ras and Rho
3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.9K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K


