在患有复发性/逆转性急性淋巴细胞白血病的儿童中,用伊诺图祖马布奥佐加米辛作为第四线救援疗法的完全缓解
Athanasios Tragiannidis1, Vassiliki Antari1, Eleni Tsotridou1
1Children & Adolescent Hematology-Oncology Unit, Second Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Hematology reports
|October 25, 2024
概括
伊诺图祖马布 (ozogamicin) 有效治疗复发性B细胞急性淋巴细胞白血病 (ALL),耐化学疗和新药. 这种救援疗法实现了最小的残留疾病负面影响,使得小儿病患者的干细胞移植成功.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 免疫治疗是一种免疫疗法.
背景情况:
- 复发或不耐药的儿童急性淋巴细胞白血病 (ALL) 仍然是一个重要的治疗挑战,尽管生存率有所改善.
- 伊诺图祖马布 (inotuzumab ozogamicin) 是FDA批准的CD22定向抗体-药物结合物,用于成人和儿科患者 (≥1岁) 复发性/耐药性CD22阳性B细胞前体ALL.
研究的目的:
- 介绍一项关于非标签使用伊诺图祖马布 (inotuzumab) 奥佐加米辛 (ozogamicin) 作为耐火性B-ALL儿科患者的救援疗法的案例研究.
- 评估伊诺图祖马布 (inotuzumab) 奥佐加米辛在患者的疗效和安全性,该患者之前多次治疗失败.
主要方法:
- 一个23个月大的女孩患有高风险的B-ALL和早期孤立的髓性复发,接受了常规化疗,布利纳图莫马布和弗鲁达拉宾/赛塔拉宾/博特佐米布的治疗,但没有达到缓解.
- 非标签的伊诺图祖马布 (inotuzumab ozogamicin) 由于在淋巴细胞上具有较高的CD22表达,因此在28天的周期中使用.
- 对最小残留疾病 (MRD) 进行了监测.
主要成果:
- 在接受伊诺图祖马布 (inotuzumab) 奥佐加米辛治疗后,该患者在28日实现了0.08%的MRD.
- 持续使用伊诺图祖马布 (inotuzumab ozogamicin) 导致了MRD负面反应.
- 该患者成功地接受了来自匹配的家庭捐赠者的全源干细胞移植.
结论:
- 伊诺图祖马布 (inotuzumab ozogamicin) 证明了作为复发性B-ALL常规化疗,布利纳图莫马布和博尔特佐米布耐药的救援治疗的有效性和安全性.
- 这一案例证实了伊诺图祖马布 (inotuzumab) 奥佐加米辛在重度预治疗的儿科B-ALL患者中具有高CD22表达的潜在作用.
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