环境金属和生理压力对脂质调节失调的综合影响
Emmanuel Obeng-Gyasi1,2, Yvonne R Ford3
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
Medical sciences (Basel, Switzerland)
|October 25, 2024
概括
暴露于重金属和慢性生理压力显著影响心血管疾病的风险,通过负面影响脂质特征,包括胆固醇和甘油三. 解决环境毒素和压力对于减少心脏病的公共卫生战略至关重要.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 生物标志物 生物标志物
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 风险因素包括遗传,环境和行为.
- 这项研究研究重金属,生理压力 (全静电负荷) 和心血管疾病风险标志物 (脂质概况).
研究的目的:
- 检查重金属暴露 (,),静态负荷和脂质概况之间的关系.
- 使用NHANES 2017-2018数据来识别协会.
- 了解对心血管疾病风险的影响.
主要方法:
- 使用结构方程建模 (SEM).
- 分析了血液中和的含量.
- 从生物标志物和评估的脂质指标 (LDL,HDL,甘油三) 推导出静态负荷 (AL) 指数.
主要成果:
- 暴露于重金属 (,) 与增加的LDL和甘油三显著相关.
- 较高的全静电负荷与增加的LDL,甘油三和降低的HDL有关.
- 年龄与LDL和甘油三素正相关,与HDL负相关.
结论:
- 环境污染物和生理压力导致脂质失调,这是心血管疾病风险因素.
- 需要综合公共卫生战略来应对环境暴露和压力.
- 进一步的研究应该探索心血管风险缓解的机制和干预措施.
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