在健康和疾病中的空气污染媒介微生物失调症:肺肠轴和超越
Md Habibul Hasan Mazumder1,2,3, Salik Hussain1,2,4
1Department of Physiology, Pharmacology & Toxicology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Journal of xenobiotics
|October 25, 2024
概括
空气污染会破坏肺部和肠道微生物群,导致失能,并可能导致肺部和全身疾病. 微生物组疗法可能为未来的肺部健康带来好处.
科学领域:
- 环境健康 环境健康
- 微生物学 微生物学
- 肺部病理学 肺部病理学
背景情况:
- 肺和肠道微生物组在健康和疾病中发挥着关键作用.
- 空气污染暴露越来越多地与肺部和肠道中的微生物失衡有关.
- 微生物失生症是空气污染对健康有害影响的一个拟议机制.
研究的目的:
- 审查和讨论空气污染如何改变人类和小鼠的肺部和肠道微生物组.
- 探索这些微生物组改变在健康和疾病中的作用.
- 在空气污染介导的病理中检查肺-肝-肠轴.
主要方法:
- 文献综述和综合有关空气污染和微生物群相互作用的当前研究.
- 对因环境暴露而导致微生物失生症的机制的分析.
- 讨论现有数据和潜在的未来研究方向.
主要成果:
- 空气污染通过氧化应激,屏障破坏和炎症诱导微生物组失调.
- 肺部和肠道中的微生物不平衡与肺部和全身疾病有关.
- 肺-肝-肠轴与空气污染对健康的影响有关.
结论:
- 空气污染显著影响肺部和肠道微生物群,导致疾病.
- 了解这些相互作用对于开发有针对性的疗法至关重要.
- 基于微生物组的干预措施有望改善肺部健康并减轻与污染相关的疾病.
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