饮食摄入与肺胸部的关联:孟德尔的随机化研究
Qichen Liang1, Huimin Ma2, Liming Zhang1
1School of Clinical Medicine, Jining Medical University, Jining, Shandong 272000, PR China.
Heliyon
|October 25, 2024
概括
这项研究使用了门德尔的随机化方法,发现吃更多的新鲜水果和干水果可能会降低肺胸病的风险,而加工肉类的摄入可能会增加肺胸病的风险,强调饮食.
科学领域:
- 遗传学和营养流行病学
- 呼吸系统医学 呼吸系统医学
- 胃肠病学 胃肠病学
背景情况:
- 以前的研究表明,饮食习惯和肺部疾病之间存在联系.
- 人们越来越认识到肠肺轴及其在呼吸系统疾病中的作用.
- 肺胸炎是一种严重的肺部疾病,可能受到饮食因素的影响.
研究的目的:
- 调查各种饮食摄入量与肺胸部风险之间的因果关系.
- 探索肺肠轴在肺胸部发育中的潜在作用.
- 为了确定可能影响肺胸病风险的特定饮食成分.
主要方法:
- 使用双样本和多样本的门德尔随机化 (MR) 分析.
- 检查了24个饮食摄入变量,以确定它们与肺胸部的关联.
- 采用多种统计方法,包括反变量加权 (IVW),加权中位数估计器 (WME) 和MR-Egger回归来进行强大的因果推断.
主要成果:
- 确定了符合严格标准的饮食摄入量的显著遗传关联 (p < 5 × 10−8).
- 在肺胸部和三个饮食摄入量之间发现了因果关系.
- 增加新鲜水果和干水果的消费与肺胸病风险降低有关 (分别为OR=0.196,OR=0.323).
- 更高的加工肉类摄入量与肺胸部风险增加有关 (OR=2.705).
结论:
- 门德尔的随机化分析提供了强有力的证据,证明饮食和肺部胸部之间的因果关系.
- 饮食因素,包括水果消费和加工肉类摄入,在肺胸病风险中起作用.
- 这些发现提高了对肺胸病因和肺肠轴机制的理解.
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