聚乙烯纳米和微塑料对人类乳腺上皮细胞和人类乳腺癌细胞的影响
Maximilian Schnee1, Mareike Sieler1, Jessica Dörnen1,2
1Institute of Immunology, Center for Biomedical Research and Education (ZBAF), Witten/Herdecke University, Witten, Germany.
Heliyon
|October 25, 2024
概括
聚钢 (PS) 纳米和微塑料被人类乳腺细胞吸收,可能会影响癌症的进展. 研究表明,PS颗粒可以影响细胞增殖和迁移,突出显示健康风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 越来越多的环境塑料污染导致了广泛的纳米和微塑料污染.
- 纳米和微塑料吸收和积累对人类健康的影响尚未得到充分研究,特别是在癌症方面.
研究的目的:
- 研究聚乙烯 (PS) 纳米和微塑料在人类乳腺上皮和癌细胞中的吸收.
- 确定PS颗粒对细胞增殖,殖民地形成,乳球形成,细胞融合和迁移的影响.
主要方法:
- 暴露人类乳腺上皮细胞 (M13SV1_Syn1-DSP8-11) 和人类乳腺癌细胞 (MDA-MB-231-DSP1-7) 不同大小和剂量的PS颗粒.
- 基于颗粒度,剂量和细胞系的PS颗粒吸收的评估.
- 评估细胞反应,包括增殖,殖民地和哺乳球形成,细胞融合和迁移.
主要成果:
- 根据颗粒大小,剂量和细胞系,PS颗粒的吸收有显著的变化,在癌细胞中吸收率更高.
- 没有观察到殖民地形成能力或细胞融合的显著增加.
- 发现了轻微的剂量和细胞系依赖的刺激作用,对细胞增殖和细胞迁移产生影响.
结论:
- 聚乙烯纳米和微塑料被人类乳腺细胞吸收,包括癌细胞.
- 聚氨酸颗粒可以影响细胞过程,如增殖和迁移,这表明它可能在癌症进展中发挥作用.
- 需要进一步的研究才能充分了解纳米和微塑料暴露对健康的长期影响.
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