格林素对于降低的血压至关重要
Kazuma Matsui1, Takanori Ida2, Kanae Oishi1
1Division of Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan.
Frontiers in endocrinology
|October 25, 2024
概括
格林对于降低小鼠每日昏迷期间的血压至关重要. 这种激素通过抑制交感神经活动来积极降低血压,这是诱导的关键机制.
科学领域:
- 生理学 生理学 生理学
- 内分泌学 在内分泌学.
- 心血管科学 心血管科学
背景情况:
- 每日麻木是一种低温状态,在禁食期间观察到一些动物,经常伴随着血压降低.
- 在昏迷期间调节血压的精确机制仍然不完全理解.
- 格林是一种氧化激素,已知会诱导低温,在禁食期间分泌,与心血管系统中的受体.
研究的目的:
- 为了研究格林在调节血压中的作用,在诱导每日的过程中.
- 为了测试格雷林积极控制与 associated 相关的血压变化假设.
主要方法:
- 使用雄性野生型和缺乏格林基因的小鼠 (10周大).
- 在禁食诱导的昏迷期间使用遥测系统持续测量血压.
- 分析心率变化以评估交感神经活动.
- 用一种格林受体激活剂 (GHRP-6) 来观察其作用.
主要成果:
- 缺乏格林林基因的小鼠在诱导的过程中没有表现出典型的血压下降.
- 发现在饥饿期间,在缺乏格林林的小鼠中,交感神经活动占主导地位.
- 给予格林受体激动剂使血压和心率变化在缺陷小鼠中正常化,模仿野生类型的反应.
结论:
- 格林在昏迷期间降低血压方面发挥着重要,积极的作用.
- 这种降低血压的媒介是格林抑制同情神经活动.
- 格林是快速诱导的的过程中心血管适应的关键调节者.
相关概念视频
Regulation of Food Intake
199
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
199
Hormonal Regulation of Blood Pressure
2.5K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.5K
Hormonal Regulation
43.2K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.2K
Neural Regulation of Blood Pressure
2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
Primary Motives: Hunger and Thirst
162
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
162
Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K


