Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Extracellular Matrix01:42

The Extracellular Matrix

81.5K
Overview
81.5K
Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

371
Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
Next,...
371
Mesh Analysis with Current Sources01:10

Mesh Analysis with Current Sources

1.2K
Mesh analysis becomes simpler when analyzing circuits with current sources, whether independent or dependent. The presence of current sources reduces the number of equations required for analysis. Two cases illustrate this:
Current Source in One Mesh: The analysis process is straightforward when a current source is found in only one mesh within the circuit. Mesh currents are assigned as usual, with the mesh containing the current source excluded from the analysis. Kirchhoff's voltage law...
1.2K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.6K
Mesh Analysis01:20

Mesh Analysis

569
Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved.
A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
569
Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

3.0K
The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
3.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

TabularQual: A spreadsheet-based format for annotating and curating logical models in SBML-qual.

bioRxiv : the preprint server for biology·2026
Same author

Leveraging training expertise to build capacity in computational personalised medicine.

Bioinformatics advances·2026
Same author

Contextualising multimorbidity in people who use drugs: analysis of drug-death decedents in Scotland.

Irish journal of psychological medicine·2025
Same author

Data-driven inference of Boolean networks from transcriptomes to predict cellular differentiation and reprogramming.

NPJ systems biology and applications·2025
Same author

NeKo: A tool for automatic network construction from prior knowledge.

PLoS computational biology·2025
Same author

Reproducible Boolean model analyses and simulations with the CoLoMoTo software suite: a tutorial.

Interface focus·2025
Same journal

Graphical and interactive spatial proteomics image analysis workflow.

GigaByte (Hong Kong, China)·2026
Same journal

Closely related, yet phenotypically different - Genome assemblies of two sister species of widow spiders: <i>Latrodectus hasselti</i> and <i>L. katipo</i>, Theridiidae.

GigaByte (Hong Kong, China)·2026
Same journal

ChestPathCT5-S100: an open real-world chest CT dataset of five common thoracic pathologies with heterogeneous acquisition conditions.

GigaByte (Hong Kong, China)·2026
Same journal

AortaSeg-60: an open real-world CT-angiography dataset of the aorta with automated segmentation masks and pathological variability.

GigaByte (Hong Kong, China)·2026
Same journal

A chromosome-level reference genome for Pacific herring (<i>Clupea pallasii)</i> from the Bering Sea.

GigaByte (Hong Kong, China)·2026
Same journal

Efficient downsampling of genome alignments with Rasusa.

GigaByte (Hong Kong, China)·2026
查看所有相关文章

相关实验视频

Updated: Jun 9, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

3.4K

PhysiMeSS - 一个新的physiCell附加组件用于细胞外矩阵建模.

Vincent Noël1,2,3, Marco Ruscone1,2,3,4, Robyn Shuttleworth5

  • 1Institut Curie, Université PSL, F-75005, Paris, France.

GigaByte (Hong Kong, China)
|October 25, 2024
PubMed
概括
此摘要是机器生成的。

PhysiMeSS引入了一种新的代理类型,用于在基于代理的模拟中将细胞外矩阵 (ECM) 建模为纤维. 这增强了瘤微环境建模,用于研究癌症转移和ECM相关疾病.

更多相关视频

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
07:40

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM

Published on: February 11, 2022

2.1K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

9.7K

相关实验视频

Last Updated: Jun 9, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

3.4K
Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
07:40

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM

Published on: February 11, 2022

2.1K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

9.7K

科学领域:

  • 计算生物学 计算生物学
  • 癌症研究 癌症研究
  • 生物物理学的生物物理.

背景情况:

  • 细胞外基质 (ECM) 提供结构支持,并影响癌症转移.
  • 现有的基于代理的框架,如PhysiCell模型细胞作为简单的形状,限制ECM表示.
  • 精确的ECM光纤网络建模对于理解瘤微环境动态至关重要.

研究的目的:

  • 引入一种新型的代理类型,用于在基于代理的模拟中表示细胞外矩阵纤维.
  • 开发一个 PhysiCell 的扩展,命名为 PhysiMeSS,能够模拟纤维-细胞和纤维-纤维相互作用.
  • 为研究与ECM失调和癌症转移有关的疾病提供计算工具.

主要方法:

  • 开发了PhysiMeSS作为一个对PhysiCell框架的补充.
  • 引入了一个新的代理类型,代表ECM纤维的线段 (2D) 或圆柱体 (3D).
  • 实现了纤维剂,细胞剂和其他纤维剂之间的物理相互作用.

主要成果:

  • PhysiMeSS成功地扩展了PhysiCell,将细胞外矩阵模型作为纤维网络.
  • 该框架允许模拟细胞和ECM纤维之间的物理相互作用.
  • 通过展示其能力的例子展示了PhysiMeSS的实用性.

结论:

  • PhysiMeSS提供了一种新的计算方法,用于在基于代理的模拟中建模细胞外矩阵.
  • 该工具增强了复杂生物过程的研究,包括癌细胞入侵和ECM相关的病理.
  • PhysiMeSS促进了与细胞外矩阵失调和癌症转移有关的疾病的研究.