杜洛特格拉维尔过量自杀:一个案例报告
Rahul Daimari1,2, Lawrence Kwape1,2, Anthony A Oyekunle1,2
1Department of Internal Medicine, University of Botswana, Botswana.
Southern African journal of HIV medicine
|October 25, 2024
概括
一名患者在大量过量服用HIV整合酶抑制剂杜洛特格拉维尔 (DTG) 后幸存下来,仅出现轻微症状. 这个案例突出了DTG的重点.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 多卢特格拉维尔 (DTG) 是艾滋病毒治疗的首选整合酶抑制剂,因为它具有有效性,耐受性和最小的药物相互作用.
- 博茨瓦纳在2017年实施了一项"全方位治疗"政策,推基于DTG的方案用于一线HIV治疗.
- 抗逆转录病毒疗法 (ART) 对于治疗艾滋病毒感染至关重要.
研究的目的:
- 在艾滋病毒阳性患者中报告一个显著的多卢特格拉维尔 (DTG) 过量服用病例.
- 为了评估大量DTG摄入后的临床表现和结果.
- 评估在药物过量后重新启动基于DTG的ART的安全性.
主要方法:
- 一个29岁的HIV感染男性患者的病例报告.
- 患者故意摄入了1500毫克的多卢特格拉维尔 (DTG).
- 进行了临床监测,实验室检测 (血细胞计数,肝功能,肌素) 和心电图.
主要成果:
- 在DTG过量后,患者经历了吐,腹上疼痛和头等自我限制的症状.
- 最初的实验室测试和心电图是正常的; 血清肌素的非渐进性增加被注意到.
- 患者在一个月的中断后成功地恢复了基于DTG的ART,没有任何不良影响.
结论:
- 杜鲁特格拉维尔 (DTG) 似乎具有良好的安全性,即使在过量服用的情况下也是如此.
- 在大量的DTG摄入后,可能会出现轻微的过渡症状.
- 在过量服用后重新开始基于DTG的抗逆转录病毒疗法是可行的和安全的.
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