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针对三阴性乳腺癌上皮质-介质细胞转换的向治疗方法

Mazharul Haque¹, Ritis K Shyanti¹, Manoj K Mishra¹

¹Cancer Research Center, Department of Biological Sciences, Alabama State University, Montgomery, AL, United States.

Frontiers in oncology

|October 25, 2024

概括

三重阴性乳腺癌 (TNBC) 侵袭和转移与上皮细胞转移到介质细胞转移 (EMT) 有关. 向疗法显示出通过抑制关键信号通路来治疗这种攻击性癌症亚型的希望.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

三阴性乳腺癌 (TNBC) 是一种缺乏ER,PR和HER2表达的侵袭性亚型,占乳腺癌病例的15-20%.
瘤微环境,包括细胞外基质 (ECM),在TNBC进展中起着至关重要的作用.
皮质转介质转换 (EMT) 涉及TNBC入侵和转移,使其标记物成为潜在的治疗点.

研究的目的:

审查最近在TNBC入侵和转移中了解EMT的进展.
探索TNBC新兴的向治疗策略.

主要方法:

在TNBC中对EMT研究的文献综述.
针对性治疗方法的分析,包括信号通路抑制剂和免疫检查点抑制剂.

主要成果:

在TNBC细胞增殖,迁移,入侵和转移方面,EMT对TNBC细胞的增殖,迁移,入侵和转移有显著的作用.
针对性疗法,如TGF-β,Wnt/β-catenin,Notch,TNF-α/NF-κB和EGFR的抑制剂,显示出潜在的潜力.
正在探索免疫检查点抑制剂,如pembrolizumab和PARP抑制剂 (例如olaparib,talazoparib).

结论:

在TNBC转移中,EMT是关键过程,并提出了可行的治疗点.
向疗法为TNBC提供了化疗的有希望的替代方案,其疗效提高,副作用减少.

关键词:

乳腺癌乳腺癌乳腺癌表皮细胞-介质细胞过渡.监管路径监管路径有针对性的治疗.三重阴性乳腺癌是什么瘤微环境是一个微环境.

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