苏丹2型糖尿病心血管疾病患者血葡萄糖,HbA1c,胰岛素和脂质概况:一个病例对照研究
Salsabbil Idris Abdallah1, Nuha Eljailli Abubaker1, Mariam Abbas Ibrahim1
1Clinical Chemistry Department, Sudan University of Science and Technology,, Khartoum, Khartoum, 11111, Sudan.
这项研究发现,苏丹2型糖尿病患者患有心血管疾病的BMI,葡萄糖,HbA1c,HDL-C和胰岛素水平较高. 疾病持续时间的延长与葡萄糖,HbA1c和胰岛素正相关,与脂质负相关.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题,预计到2030年将影响4.39亿人.
- 心血管并发症显著影响T2DM患者的结果.
- 了解T2DM中的代谢概况对于管理并发症至关重要.
研究的目的:
- 调查苏丹T2DM患者的血葡萄糖,HbA1c,胰岛素和脂质资料.
- 为了比较T2DM患者与心血管疾病患者之间的这些标志物.
- 探索代谢标志物与疾病持续时间之间的相关性.
主要方法:
- 一项涉及330名苏丹T2DM患者 (165例心血管疾病,165例没有) 的病例控制研究.
- 使用Mindray BS-480自动分析仪测量了血葡萄糖,HbA1c和脂质概况.
- 用Cobase 411自分析仪分析胰岛素水平;使用SPSS v21.21分析数据.
主要成果:
- 患有心血管疾病的患者的BMI,禁食血糖 (FBG),HbA1c,HDL-C和胰岛素水平显著提高 (p<0.05).
- 与男性相比,女性的总胆固醇 (TC),LDL-C,HDL-C和BMI显著增加 (p<0.001).
- 在FBG,HbA1c,胰岛素和疾病持续时间 (p<0.05) 之间观察到显著的正相关性.
结论:
- 患有心血管疾病的T2DM患者呈现高BMI,FBG,HbA1c,HDL-C和胰岛素.
- 疾病持续时间与FBG,HbA1c和T2DM患者的胰岛素水平有关.
- 这些发现突显了代谢失调,心血管风险和T2DM疾病进展之间的复杂相互作用.
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