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在高血压缺血症的条件下,损害了内皮前体细胞与内皮细胞的外体通信

Shuzhen Chen¹, Venkata Polaki², Ji C Bihl¹

¹Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.

Frontiers in stroke

|October 25, 2024

概括

高血压会损害内皮原生细胞 (EPC) 衍生的外体细胞 (EPC-EXs),减少它们在缺血期间对内皮细胞 (ECs) 的保护作用. 这种受损的外体通信可能会使高血压患者的中风损伤恶化.

科学领域:

心血管生物学心血管生物学
细胞和分子医学是细胞和分子医学.
异构体生物学异构体生物学

背景情况:

源自内皮原生细胞 (EPC) 的外体细胞 (EPC-EXs) 保护内皮细胞 (ECs) 免受缺氧损伤.
在高血压中,EPC功能下降,这表明高血压-缺血症的情况中,EPC-EX功能发生了改变.

研究的目的:

研究高血压对EPC-EXs的影响及其在高血压-缺血症条件下与ECs的通信.
评估来自高血压小鼠EPCs的外体的保护潜力,与正常血压对照相比.

主要方法:

来自野生类型 (WT) 和高血压雷宁转基因 (R+) 鼠的骨髓EPC的EPC-EXs.
在使用血管素II (Ang II) 和缺氧/逆氧化治疗的EC中诱导高血压-缺血损伤.
在复氧化过程中与WT-EPC-EXs或R-EPC-EXs共同培养EC,以评估外体细胞吸收,EC活力和血管功能.

主要成果:

与WT-EPC-EXs相比,ECs的R-EPC-EXs的整合效率明显较低.
患有高血压-缺血性损伤的ECs表现出降低活力,增加细胞亡和血管生成障碍.
与R-EPC-EXs相比,WT-EPC-EXs可以更好地保护ECs免受高血压-缺血损伤.

结论:

在高血压-缺血症条件下,EPC和EC之间的EPC外基因组介导通信受到损害.
损坏的EPC外体通信可能会导致高血压相关的缺血性中风中脑性缺血性损伤的恶化.

关键词:

内皮细胞是内皮细胞.体前代细胞是内皮前代细胞.异位体沟通异位体沟通这种高血压,高血压.缺血脑卒中中风神经元神经元的神经元

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