患者报告的流产和孕产妇并发症:状细胞病实施联盟的见解
Joacy G Mathias1, Rita V Masese2, Allison A King3
1Division of Women's Community and Population Health, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA.
概括
在状细胞疾病 (SCD) 中的怀孕导致高发症率和流产. 以前的并发症增加了复发的风险,突出了需要专门的孕前和产周护理.
科学领域:
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
- 生殖健康 生殖健康
背景情况:
- 状细胞疾病 (SCD) 在怀孕期间对母亲的健康构成重大风险.
- 与怀孕相关的并发症可能会对患有SCD的个体的孕产妇结果产生负面影响.
研究的目的:
- 确定患有SCD的个体中母亲发病率的流行率和预测因素.
- 在状细胞疾病实施联盟 (SCDIC) 注册表中分析妊娠结果.
主要方法:
- 对738名女性SCD注册参与者 (15-45岁) 的横截面分析.
- 利用了关于怀孕和相关结果的自我报告调查数据.
- 包括对1076名活产儿和报告的妊娠损失/胎儿死亡事件的分析.
主要成果:
- 20%的怀孕结果是流产或胎儿死亡.
- 75%的活产儿至少有一次并发症.
- 最常见的并发症包括疼痛危机 (61.1%) 和需要输血 (33.0%).
- 以前的并发症显著预测了后续怀孕中的复发 (例如,疼痛危机或3.13,输血或3.22).
结论:
- 在SCD中观察到高频率的流产和孕产妇并发症.
- 这些发现强调了对预孕咨询的急需性.
- 早期启动专门的围产期护理对于改善SCD中母亲的结果至关重要.
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