[智利随着年龄的增长,功能下降:性别差异和并发病的影响]
Sebastián Cabrera1, Magdalena Walbaum2, Leticia Elgueta1
1Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Revista medica de Chile
|October 25, 2024
概括
在智利,估计的淋巴细胞过率 (eGFR) 随着年龄的增长而下降,从18岁开始. 这种下降在女性和患有糖尿病和高血压等慢性疾病的人群中更为明显.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 基于血清肌素的估计膜过率 (eGFR) 对于评估功能至关重要.
- 随着年龄的增长,eGFR自然下降,并受到糖尿病,高血压和肥胖等慢性疾病的进一步影响.
- 以前缺乏关于智利人口eGFR趋势的代表性数据.
研究的目的:
- 确定智利成年人口中与年龄相关的eGFR下降情况.
- 分析性别和慢性病的存在如何影响eGFR下降.
- 为智利人口统计建立基线eGFR数据.
主要方法:
- 来自智利国家健康调查 (2009年和2017年) 的5638名成年人 (≥18岁) 的横截面分析.
- 使用CKD-EPI公式计算eGFR,该公式基于血清肌水平.
- 对eGFR下降的统计比较是跨性别和患有/没有糖尿病,高血压,血脂不良和/或肥胖的人进行的.
主要成果:
- 在男性和女性中,eGFR随着年龄的增长呈现一致的下降,与男性相比,女性的下降率更为显著 (-0.88 mL/min/1.73 m2/year),男性的下降率更为显著 (-0.78 mL/min/1.73 m2/year).
- 在eGFR的下降很早开始,从18岁开始,并均地进展.
- 患有慢性疾病的个体表现出比不患有慢性疾病的个体更急剧的EGFR下降 (-0.94毫升/分钟/1.73毫米/年),患有慢性疾病的女性表现出最明显的下降 (-1.00毫升/分钟/1.73毫米/年).
结论:
- 智利人口年龄增长时,eGFR逐渐下降,最早从18岁开始.
- 这种与年龄相关的衰退在女性中更为明显,并因慢性疾病的存在而加剧.
- 这些发现为解释智利各个年龄组和风险概况的eGFR值提供了必要的特定人群数据.
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