表观遗传衰老和生育能力:挪威母亲,父亲和儿童队列研究
Lise Andrea Arge1,2, Yunsung Lee1, Karoline Hansen Skåra1
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Human reproduction (Oxford, England)
|October 25, 2024
概括
这项研究没有发现强有力的证据将表观遗传年龄加速或减缓与自然受孕的夫妇的生育能力联系在一起. 需要进一步的研究来探索表观遗传衰老与两性生育参数之间的关联.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生殖生物学 生殖生物学
- 衰老研究研究 衰老研究
背景情况:
- 以前的研究将女性表观遗传年龄加速与不良生育结果和试管婴儿使用联系起来.
- 精子中的表观遗传衰老与不利的精子参数有关.
- 对自然受孕个体的表观遗传衰老和生育能力的研究是有限的.
研究的目的:
- 调查男性和女性表观遗传年龄加速/减速和生育能力之间的关联.
- 探索表观遗传衰老在自然受孕中的作用.
主要方法:
- 利用了挪威母亲,父亲和儿童队列研究 (MoBa) 中1657对夫妇的数据.
- 从血液样本中测量DNA甲基化水平,使用Illumina甲基化EPIC阵列.
- 用线性回归来分析表观遗传生物标志物,用比例概率回归来分析生育率,调整以考虑混因素.
主要成果:
- 没有发现任何令人信服的证据表明表观遗传年龄加速/减缓和生育能力之间存在关联.
- 在男性中观察到,随着表观遗传年龄加速而增加生育能力的轻微而非强烈的趋势 (DunedinPACE时钟).
- 在两性中都发现了生物衰老和生育能力之间的弱弱和相互矛盾的非线性关联.
结论:
- 这些发现与先前对受精治疗群体的研究形成鲜明对比,表明在自然受孕中表观遗传衰老效应较弱.
- 该研究的怀孕队列设计可能会限制对所有试图怀孕的夫妇的概括性.
- 建议对基于血液的表观遗传衰老加速和男性和女性的生育指标进行进一步的研究.
相关概念视频
01:21Nondisjunction
3.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.8K
03:09Meiosis I
38.8K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
38.8K
02:30Genomic Imprinting and Inheritance
33.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.4K
02:07Oogenesis
63.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.5K
02:27Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K