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Updated: Jun 9, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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JMJD1C形成凝结物,以促进多种类型的AML细胞共享的RUNX1依赖基因表达程序

Qian Chen1, Saisai Wang1, Juqing Zhang2

  • 1State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.

Protein & cell
|October 25, 2024
PubMed
概括

含有1C (JMJD1C) 的Jumonji域对急性髓性白血病 (AML) 细胞存活至关重要. JMJD1C与RUNX1相互作用,促进一个转录程序,支持跨多种AML亚型的白血病细胞存活.

关键词:
在 JMJD1C 里面.在RUNX1中,使用RUNX1.急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.增强剂-促进剂的相互作用.酶活性 独立的功能 独立的功能阶段分离的阶段分离.

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