长期暴露于多环芳化合物会改变皮肤病毒组合和病毒与宿主相互作用
Shicong Du1, Xinzhao Tong1,2, Marcus H Y Leung1
1School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China.
The ISME journal
|October 25, 2024
概括
空气污染中的多环芳 (PAH) 改变了皮肤病毒和细菌. 高水平的PAH暴露会转移病毒功能,以促进持久细菌的生物降解,影响皮肤健康.
科学领域:
- 环境微生物学环境微生物学
- 病毒学 病毒学
- 皮肤病学 皮肤病学
背景情况:
- 来自空气污染的多环芳 (PAH) 影响皮肤微生物组合和皮肤表型.
- 氧化的对皮肤病毒体的影响及其功能作用在很大程度上是未知的.
研究的目的:
- 研究PAH暴露对皮肤病毒组成,功能和宿主病毒相互作用的影响.
- 了解这些相互作用如何影响细菌代谢和皮肤表型.
- 探索病毒在皮肤微生物群落适应PAH污染中的作用.
主要方法:
- 从124名中国妇女的脸皮肤抽样中分析了元基因组.
- 在不同水平的PAH暴露下,皮肤病毒组的比较.
- 研究病毒功能,宿主微生物相互作用和代谢基因转移.
主要成果:
- 皮肤病毒表现出明显的多样性,组成,功能和生活方式,受PAH暴露和微生物群切割型的影响.
- 高度的PAH增加了病毒与生物降解细菌的相互作用,病毒富含了异生物降解功能.
- 有证据表明,菌体辅助代谢基因有助于生物降解,将相互作用模型从"赢家背后" (低PAH) 转变为"持久背后" (高PAH).
结论:
- 像PAHs这样的空气污染物显著影响皮肤细菌和病毒,改变它们的相互作用和功能.
- 病毒群体在细菌适应污染物方面发挥着作用,可能有助于异生物降解.
- 了解这些复杂的相互作用对于开发在污染环境中保持皮肤健康的策略至关重要.
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