挥发性麻醉剂是否会抑制尿液的输出?
1Karolinska Institutet at Danderyd Hospital (KIDS), Stockholm, Sweden.
Anaesthesiology intensive therapy
|October 25, 2024
概括
与propofol相比,易挥发性麻醉剂 (如异黄素和黄素) 并没有显著影响尿液输出. 这项研究发现,在手术期间对液体负荷的利尿反应没有差异.
科学领域:
- 麻醉学 麻醉学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术研究的研究.
背景情况:
- 已知异氨酸可降低尿量,但其对挥发性麻醉剂的特异性尚不清楚.
- 这项研究解决了挥发性麻醉剂是否对手术期间尿液输出有独特的影响.
研究的目的:
- 为了比较在挥发性麻醉剂和静脉麻醉下手术期间对晶体体体积负荷的利尿反应.
- 为了确定异黄素和异黄素是否影响尿液输出不同于.
主要方法:
- 分析了两项随机临床试验的数据:甲状腺手术 (异花与) 和子宫切除术 (七花与).
- 使用人口体积动态分析量化1.7-1.8L的林格乳酸输注的尿液输出和尿液反应的量化.
- 使用了血稀释测量 (血红蛋白,白蛋白) 和尿液输出数据用于动力建模.
主要成果:
- 在甲状腺手术期间,isoflurane和propofol组之间尿液输出没有统计学上显著的差异 (P=0.50).
- 在子宫切除术期间,赛沃弗兰和普罗波福尔组之间尿液输出没有显著差异 (P=0.81).
- 对体积,体重和血膨胀进行调整后的动力学分析显示,两组的利尿剂反应没有显著差异.
结论:
- 异黄和异黄没有比propofol更强的利尿作用.
- 使用挥发性麻醉剂观察到的尿液输出的减少不是特定的,并且与静脉内麻醉效应相比较.
相关概念视频
Inhalational Anesthetics: Overview
217
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
217
Parenteral Anesthetics: Overview
104
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
104
Local Anesthetics: Pharmacokinetics
735
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
735
Local Anesthetics: Clinical Application as Epidural Anesthesia
414
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
414
General Anesthesia: Overview
196
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
196
Local Anesthetics: Adverse Effects
392
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
392


