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相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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使用半固体挤出开发个性化的即时释放凝制剂.

Morenikeji Aina1, Fabien Baillon1, Romain Sescousse1

  • 1RAPSODEE, IMT Mines Albi, CNRS, University of Toulouse, 81013 Albi, France.

Gels (Basel, Switzerland)
|October 25, 2024
PubMed
概括

3D打印为早产婴儿创造了个性化的凝药物,提高了剂量准确性和安全性. 这种新的方法确保了可靠的药物输送,克服了手动剂量调整的局限性.

关键词:
这是一个很好的方法.批量变化的可能性.咖啡因 咖啡因是一种咖啡因.强制降解降解的强制性降解基烯甲基纤维素 (HPMC) 是一种立即释放 立即释放个性化药物是个性化的药物.半固体挤出方式稳定的稳定性 稳定的稳定性

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科学领域:

  • 制药技术 制药技术 制药技术
  • 生物材料科学 生物材料科学
  • 新生儿医学 新生儿医学

背景情况:

  • 新生儿手动剂量调整容易出现错误,污染和精度降低.
  • 优化治疗结果需要准确的药物输送,特别是对于早产婴儿等弱势群体.
  • 现有的儿科用剂量的方法缺乏为最佳患者护理所需的个性化.

研究的目的:

  • 开发和评估个性化的,基于凝的咖啡因剂量形式,使用半固体挤出3D打印 (SSE 3DP).
  • 评估3D打印剂型的精度,可重复性和药物释放特性.
  • 为了证明SSE 3DP在定制新生儿药物中的潜力.

主要方法:

  • 利用和基甲基纤维素来制备SSE 3DP.最佳的质性质的水凝.
  • 为特定的新生儿设计和打印个性化的咖啡因凝剂型,精确调整体积和含量.
  • 在三个生产批次中进行了可重复性评估,并进行了强制降解研究.

主要成果:

  • 液凝配方表现出了出色的可打印性和形状保留性.
  • 在个性化剂量中实现了高咖啡因恢复 (103.46%),证明了精确的药物含量控制.
  • 生产批量显示出最小的变化,证实了工艺的可重复性.
  • 降解研究表明,咖啡因在凝基质中的化学完整性.
  • 打印的药剂表格表现出即时释放的特征,超过80%的咖啡因在45分钟内释放.

结论:

  • 半固体挤出3D打印为创建个性化的基于凝的药物递送系统提供了精确和可重复的方法.
  • 这项技术克服了传统手动剂量的局限性,提高了新生儿护理的安全性和有效性.
  • 3D打印的凝配方对量身定制的药物解决方案具有显著的前景,特别是对于早产婴儿.