使用半固体挤出开发个性化的即时释放凝制剂
Morenikeji Aina1, Fabien Baillon1, Romain Sescousse1
1RAPSODEE, IMT Mines Albi, CNRS, University of Toulouse, 81013 Albi, France.
Gels (Basel, Switzerland)
|October 25, 2024
概括
3D打印为早产婴儿创造了个性化的凝药物,提高了剂量准确性和安全性. 这种新的方法确保了可靠的药物输送,克服了手动剂量调整的局限性.
科学领域:
- 制药技术 制药技术 制药技术
- 生物材料科学 生物材料科学
- 新生儿医学 新生儿医学
背景情况:
- 新生儿手动剂量调整容易出现错误,污染和精度降低.
- 优化治疗结果需要准确的药物输送,特别是对于早产婴儿等弱势群体.
- 现有的儿科用剂量的方法缺乏为最佳患者护理所需的个性化.
研究的目的:
- 开发和评估个性化的,基于凝的咖啡因剂量形式,使用半固体挤出3D打印 (SSE 3DP).
- 评估3D打印剂型的精度,可重复性和药物释放特性.
- 为了证明SSE 3DP在定制新生儿药物中的潜力.
主要方法:
- 利用和基甲基纤维素来制备SSE 3DP.最佳的质性质的水凝.
- 为特定的新生儿设计和打印个性化的咖啡因凝剂型,精确调整体积和含量.
- 在三个生产批次中进行了可重复性评估,并进行了强制降解研究.
主要成果:
- 液凝配方表现出了出色的可打印性和形状保留性.
- 在个性化剂量中实现了高咖啡因恢复 (103.46%),证明了精确的药物含量控制.
- 生产批量显示出最小的变化,证实了工艺的可重复性.
- 降解研究表明,咖啡因在凝基质中的化学完整性.
- 打印的药剂表格表现出即时释放的特征,超过80%的咖啡因在45分钟内释放.
结论:
- 半固体挤出3D打印为创建个性化的基于凝的药物递送系统提供了精确和可重复的方法.
- 这项技术克服了传统手动剂量的局限性,提高了新生儿护理的安全性和有效性.
- 3D打印的凝配方对量身定制的药物解决方案具有显著的前景,特别是对于早产婴儿.
关键词:
这是一个很好的方法.批量变化的可能性.咖啡因 咖啡因是一种咖啡因.强制降解降解的强制性降解基烯甲基纤维素 (HPMC) 是一种立即释放 立即释放个性化药物是个性化的药物.半固体挤出方式稳定的稳定性 稳定的稳定性更多相关视频
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