一个可穿戴的体外CO2去除系统,具有闭环反
Andrew Zhang1,2, Brian J Haimowitz1, Kartik Tharwani1
1Extracorporeal Life Support Laboratory, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
本研究介绍了一种新型可穿戴的体外二氧化碳去除 (ECCO2R) 系统原型. 它自动调整代谢变化,使呼吸衰竭患者能够进行物理治疗.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 身体外的二氧化碳去除系统 (ECCO2R) 有助于重度呼吸衰竭患者.
- 健行和物理治疗改善了结果,但受到当前ECCO2R系统批量和代谢变异性的阻碍.
研究的目的:
- 开发和测试可穿戴ECCO2R系统的第一个原型.
- 创建一个系统,动态调整到患者的代谢和酸变化.
主要方法:
- 开发了一个可穿戴的ECCO2R系统,使用废气CO2 (EGCO2) 作为血液CO2 (pCO2) 的代理.
- 集成的双吹风机调节基于实时EGCO2反的扫气流.
- 在模拟的代谢条件下对水进行了24小时的体外试验,并对绵羊血液进行了一次试验.
主要成果:
- 该系统迅速调整了扫气,在受到不同入口pCO2的挑战时,在1分钟内达到EGCO2目标.
- 在流量变化下,负反控制更有效地维持了目标EGCO2,而不是固定扫除气.
- 在全血中确认了系统功能.
结论:
- 这种可穿戴的ECCO2R原型代表了响应性体外支持的重大进步.
- 该技术有助于物理治疗,并增强患者的流动性和自主性.
- 进一步开发对于响应式可穿戴ECCO2R设备的临床转化至关重要.
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